设为首页 | 加入收藏
网站首页 本刊简介 编委会 投稿指南 过刊浏览 广告合作 网上订购 下载专区 联系我们  
三等位基因5-HTTLPR与青少年重性抑郁障碍的关联研究
作者:马静1  苏林雁1  禹顺英2  梁珊3  丁军1  冯哲1  杨帆1  高维佳1  林佳妮1  黄春香1  刘铁桥1  谢光荣1 
单位:1. 中南大学湘雅二医院精神卫生研究所  湖南 长沙 410011 
2.
 上海交通大学医学院上海市精神卫生中心遗传学实验室  上海 200030 
3.
 长沙市未成年人心理发展咨询指导中心 
关键词:5-HTTLPR rs25531 青少年抑郁症 关联分析 
分类号:R395.1
出版年,卷(期):页码:2010,18(2):142-145
摘要:

目的:探讨三等位基因5-羟色胺转运体基因连锁多态区多态性(5-HTTLPR+rs25531)与青少年重性抑郁障碍之间有无关联。方法:404名研究对象(病例187人,正常对照217人)使用SNaPshot系统进行基因分型。结果:三等位基因5-HTTLPR与青少年抑郁症是否患病、抑郁严重程度、是否共病焦虑、是否出现自杀观念/行为/企图均无关。结论:尚不能认为三等位基因5-HTTLPR与青少年重性抑郁障碍有关。

Objective: To explore whether triallelic5 -HTTLPR polymorphism (5 -HTTLPR + rs25531) is related to adolescent major depressive disorder (MDD) in Chinese Han population or not. Methods: 404 Chinese Han subjects, including 187 adolescent patients with MDD and 217 normal control students were recruited to the research. 5-HTTLPR and rs25531 were genotyped using SNaPshot system. Results: Triallelic 5-HTTLPR polymorphism was not related with the occurrence, severity of adolescent MDD, and was not related to whether adolescent MDD comorbid anxiety or with suicidal behavior/attempt/ideation or not. Conclusion: Triallelic 5-HTTLPR polymorphism is not related to adolescent MDD.

基金项目:
国家自然科学基金资助项目(30770767)
作者简介:
参考文献:

[1] Kent L,Vostanis P,Feehan C. Detection of major and minor depression in children and adolescents:Evaluation of the mood and feelings questionnaire. J Child Psychol Psychiat,1997,38(5):565-573
[2] 寇建华,杜亚松,夏黎明.长处和困难问卷(学生版)上海常模的制订.中国健康心理学杂志,2007,15(1):3-5
[3] Syagailo YV,Stober G,Grassle M,et al. Association analysis of the functional monoamine oxidase:A gene promoter polymorphism in psychiatric disorders. Am J Med Genet,2001,105(2):168-171
[4] Phillips-Bute B,Mathew JP,Blumenthal JA,et al. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med,2008,70(9):953-959
[5] Yoshida K,Naito S,Takahashi H,et al. Monoamine oxidase:A gene polymorphism,tryptophan hydroxylase gene poly mophism and antidepressant response to fluvoxamine in Japanese patients with major de pressive disorder. Prog Neuropsychopharmacol Biol Psychiatry,2002,26(7-8):1279-1283
[6] Wendland JR,Martin BJ,Kruse MR,et al. Simultaneous genotyping of four functional loci of human SLC6A4,with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry,2006,11(3):224-226
[7] Sheikh HI,Hayden EP,Singh SM,Dougherty LR,et al. An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood. Pers Individ Dif,2008,45(5):425-428
[8] Brummett BH,Muller CL,Collins AL,et al.5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet,2008,38(5):476-483
[9] Ramasubbu R,Tobias R,Bech-Hansen NT. Extended evaluation of serotonin transporter gene functional polymorphisms in subjects with post-stroke depression. Can J Psy chiatry,2008,53(3):197-201
[10] Baune BT,Hohoff C,Mortensen LS,et al. Serotonin tran sporter polymorphism (5-HTTLPR) association with melancholic depression:A female specific effect?Depress Anxiety,2008,25(11):920-925
[11] Dannlowski U,Ohrmann P,Bauer J,et al. Serotonergic genes modulate amygdala activity in major depression. Genes Brain Behav,2007,6(7):672-676
[12] Vergne DE,Nemeroff CB. The interaction of serotonin transporter gene polymorphisms and early adverse life events on vulnerability for major depression. Curr Psychiatry Rep,2006,8(6):452-457
[13] Canli T,Lesch KP. Long story short:The serotonin tran sporter in emotion regulation and social cognition. Nat Neurosci,2007,10(9):1103-1109
[14] Zhang JL,Yang JF,Chan P. No association between polymorphism of serotonin transporter gene and depression in Parkinson’ s disease in Chinese. Neurosci Lett,2009,455(3):155-158
[15] Wüst S,Kumsta R,Treutlein J,et al. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology,2009,34(7):972-982
[16] Segal J,Schenkel LC,Oliveira MH,et al. Novel allelic variants in the human serotonin transporter gene linked polymorphism (5-HTTLPR) among depressed patients with suicide attempt. Neurosci Lett,2009,451(1):79-82
[17] Kohen R,Cain KC,Mitchell PH,et al. Association of serotonin transporter gene polymorphisms with post-stroke depression. Arch Gen Psychiatry,2008,65(11):1296-1302
[18] Chan F,Lanct觝t KL,Feinstein A,et al. The serotonin transporter polymorphisms and major depression following traumatic brain injury. Brain Inj,2008,22(6):471-479

服务与反馈:
文章下载】【加入收藏
您是第访问者

《中国临床心理学杂志》编辑部
地址:湖南省长沙市中南大学湘雅二医院内, 410011
电 话:0731-85292472    电子邮件:cjcp_china@163.com