中国临床心理学杂志

The Functional Magnetic Resonance Imaging of Major Depressive Disorder in Resting State and Task State

作者：LI Yi-hui LIU Xiao-zhen LIU Ying-jun LIU Zhe-ning TANG Hong

单位：1. Department of Psychology Gannan Medical University Ganzhou 341000 China 2. School of Biomedical Engineering Southern Medical University Guangzhou 510515 China 3. Institute of Mental Health Second Xiangya Hospital of Central South University Changsha 410011 China

关键词：Cortico-thalamo-striatal circuit Task state Resting state Functional Magnetic Resonance Imaging Major Depressive Disorder

分类号：R395.1

出版年,卷(期):页码：2017,25(3):393-399

摘要：

目的：本研究通过结合任务态与静息态的fMRI数据探讨导致抑郁症患者脑功能障碍的神经病理学因素。方法：采集25例抑郁症患者、24例健康对照N-back任务和静息态fMRI数据，采用双样本t检验进行任务态数据组间比较，低频振幅（ALFF）测量静息态。结果：重度抑郁症患者在静息态下，左丘脑、壳核、脑岛、额中回及额下回活跃程度显著增高，在任务态下，双边颞下回、右丘脑、契前叶、后扣带回、顶下回及左枕上回和梭状回活跃程度减弱。结论：皮质-丘脑-纹状体回路受损可能是抑郁症患者认知功能障碍和抑郁症状严重程度的潜在神经病理学因素。

Objective: We sought to investigate the brain dysfunction in patients with major depressive disorder(MDD) by using combined task-activation and resting-state functional Magnetic Resonance Imaging(fMRI). Methods: We investigated 25 MDD patients and 24 healthy controls during a n-back working memory task and resting-state. Task-activated state helped us to identify brain areas that are associated with the processing of n-back task stimuli and its performance. The intrinsic brain resting-state activity was measured by the amplitude of low-frequency fluctuation(ALFF). Results: We found that comparing to HC, patients with MDD exhibited increased spontaneous resting state activity in the left thalamus, putamen, insula and middle and inferior frontal gyrus. During the WM task, patients with MDD showed bilateral decreased activities in the right inferior temporal gyrus, thalamus, precuneus, posterior cingulated gyrus, inferior parietal gyrus, and the left superior occipital gyrus and fusiform, relative to HC. Conclusion: The present study provides important empirical support for the hypothesis that functional impairment in the cortico-thalamo-striatal circuit is possibly the underlying neuropathological feature of cognitive impairment and severity of depressive symptoms in MDD.

基金项目：

江西省科技厅社会发展项目《儿童期创伤与心理弹性对抑郁症患者脑功能影响的fMRI研究》（20151BBG70079）

作者简介：

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