中国临床心理学杂志

BDNF Val66Met基因多态性与家庭功能的关联分析

作者：陈琛王俊杰蔡伟雄周建松王小平

单位：1. 司法鉴定科学研究院上海市法医学重点实验室(17DZ2273200) 上海市司法鉴定专业技术服务平台(16DZ2290900) 上海 200063 2. 中南大学湘雅二医院精神卫生研究所国家精神心理疾病临床研究中心国家与地方联合精神疾病诊治工程研究中心湖南省精神病学与精神卫生重点实验室长沙 400011

关键词：BDNF Val66Met|基因多态性|家庭功能|青少年罪犯

分类号：R395.1

出版年,卷(期):页码：2018,26(1):60-62

摘要：

目的：探讨脑源性营养因子BDNF Val66Met（rs6265）基因多态性与个体感知的家庭亲密度之间的关系。方法：选取BDNF基因rs6265多态性位点，采用聚合酶链式反应和连接酶检测反应（PCR-LDR）检查技术，测定142名青少年罪犯和116名普通中学生的BDNF基因多态性分布，并应用家庭适应性和亲密度量表中文版（FACESⅡCV）评估家庭功能。结果：等位基因A携带者的家庭实际亲密度和适应性显著低于GG基因型者，其亲密度和适应性的不满意度则显著高于GG基因型者。一般线性模型中，在控制组别、受教育年限及年龄后，rs6265仍与家庭亲密度、亲密度不满度显著相关（P=0.001）。结论：等位基因A携带者所感受到的家庭成员间的情感联系和家庭适应能力较GG基因型者弱，对家庭亲密度和适应性更为不满。

Objective:To study the association of brain-derived neurotrophic factor(BDNF) gene polymorphism and family cohesion. Methods:The single nucleotide polymorphism(SNPs) of BDNF, rs6265 were analyzed by PCR-LDR geno-typing assay in 258 participants(142 male juvenile offenders and 116 high school students). The Chinese version of Family Adaptability and Cohesion Evaluation Scales-Ⅱ(FACESⅡ-CV) was used to evaluate the family function. Results:Family intimacy and adaptability in A carriers were significantly lower than in GG genotype group, and unsatisfaction of intimacy and adaptability were higher in A carriers. In linear models, when controlled the age, education, whether offenders or not, family intimacy and adaptability were still significantly associated with rs6265. Conclusion:The family adaptability and emotional connection with family members are lower in A carriers than in GG groups, and A carriers feel more discontent to family intimacy and adaptability.

基金项目：

国家自然科学基金青年基金项目（81501637）；中央级公益性科研院所社会公益研究专项（GY2015G-7）

作者简介：

参考文献：

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