中国临床心理学杂志

静脉输注人脐带间充质干细胞治疗慢性失眠的临床观察

单位：1. 浙江大学医学院杭州 310058 2. 浙江武警总队医院嘉兴 314000

分类号：R395.6

出版年,卷(期):页码：2017,25(2):378-381

摘要：

目的：观察人脐带间充质干细胞移植治疗慢性失眠的有效性和安全性。方法：选择慢性失眠病人39例，随机分为移植组19例，对照组20例，移植组给予人脐带间充质干细胞移植治疗1次，对照组采用阿普唑仑口服1月，两组患者均采用SF-36健康调查简表和匹兹堡睡眠质量指数来评价临床疗效，两组患者均随访观察12个月。结果：①细胞移植组患者在细胞移植治疗后1个月生活质量评分和睡眠质量评分明显好于治疗前，并在后续的随访中持续好于治疗前；对照组口服阿普唑仑治疗后2周睡眠质量评分即开始明显好于治疗前，但治疗后3个月患者的生活质量及睡眠质量评分出现下降，且同治疗前无差异，并持续到随访结束；②两组比较发现，治疗后2周，对照组的睡眠质量评分明显高于移植组，治疗后1个月两组睡眠质量和生活质量评分无差异，治疗后2个月细胞移植组的睡眠质量评分明显好于对照组，并持续到随访结束。治疗后3个月移植组的生活质量评分明显好于对照组，并持续到随访结束；③阿普唑仑停药后对照组患者有80%出现失眠症状的反弹，而细胞移植组患者经一次治疗患者的睡眠质量和生活质量改善作用可持续12个月，并且无明显不良反应。结论：人脐带间充质干细胞静脉输注治疗可显著改善慢性失眠患者的睡眠质量和生活质量，移植后1个月起效，一次治疗作用可持续达1年之久。

Objective: To observe the efficacy and safety of human umbilical cord mesenchymal stem cells transplantation in the treatment of chronic insomnia. Methods: 39 cases of patients with chronic insomnia were randomly divided into transplantation group(n=19) and control group(n=20). The MOS item short from health survey(SF-36) and Pittsburgh sleep quality index(PSQI) were used to evaluate the clinical efficacy. Two groups of patients were followed up to 12 months. Results: ①For the cell transplantation patients, life quality score and sleep quality score were significantly better than before treatment after 1 month, and continued better than before in the follow-up period; For the comparison group patients treated with alprazolam, sleep quality score was significantly better than before treatment after 2 weeks, but the life quality score and sleep quality score decreased to the same level of before treatment after 3 months, and continued until the end of followup; ②At 2 weeks after treatment, sleep quality score in comparison group was significantly higher than transplantation group; 1 month after treatment, sleep quality score and life quality score had no significant differences between two groups; 2 months after treatment, sleep quality score in transplantation group was significantly higher than the comparison group, which continued until the end of the follow-up. 3 months after treatment, ife quality score in transplantation group was significantly higher than the comparison group, which lasted until the end of follow-up; ③For the control group, 80% patients returned to insomnia after stopping alprazolam; But for the cell transplantation group, sleep quantity and life quality improvement without obvious adverse reactions continued for 12 months after one time treatment. Conclusion: Intravenous infusion of human umbilical cord mesenchymal stem cells is effective for the chronic insomnia, which starts at 1 month after transplantation and sustains at least for 1 year.

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作者简介：

参考文献：

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