中国临床心理学杂志

计算机化认知矫正训练对精神分裂症的随机对照试验

作者：廖力维丁烨吴旭周一平潘桂花

单位：上海交通大学医学院附属精神卫生中心康复一科上海 200030

分类号：R395.5

出版年,卷(期):页码：2016,24(5):954-957

摘要：

目的：评估计算机化认知矫正训练对成年精神分裂症患者的精神症状和认知功能疗效。方法：通过随机对照试验，59名成年精神分裂症患者被分为常规药物治疗和计算机化认知矫正训练加药物的合并治疗组，采用简明精神病评定量表（BPRS）和成套认知功能测评系统评估精神症状和认知功能的改变。结果：与单一药物治疗组（分别为7.5±1.9和11.9±4.2）相比，30次合并治疗明显提高了精神分裂症患者对数字序列（正序）（8.41±1.43）和Stroop词语（14.1±1.9）测试得分（P<0.05），对精神症状疗效不明显。结论：计算机化认知矫正训练可以改善精神分裂症患者部分言语工作记忆和执行抑制功能。

Objective: To evaluate efficacy of the Computerized Cognitive Remediation Therapy to adult patients with schizophrenia. Methods: In a randomized controlled trial, 59 adult patients with schizophrenia received 30 sessions of combined treatment of the Computerized Cognitive Remediation Therapy and antipsychotics or monotherapy of antipsychotic. Outcome measures included Brief Psychiatric Rating Scale(BPRS) and a set of computerized cognitive tests measuring processing speed, attention, verbal working memory, visual memory and selective inhibition. Results: Compared to monotherapy of antipsychotic, the combined therapy improved the patients on digital sequence test and Stroop-word task(P<0.05). While the combined therapy showed little efficacy on psychiatrical symptoms. Conclusion: the Computerized Cognitive Remediation Therapy may improve verbal working memory and selective attention of adult patients with schizophrenia.

基金项目：

2014年上海市精神卫生中心院级课题（基金号：2014-YJ-02）

作者简介：

参考文献：

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