中国临床心理学杂志

阿尔兹海默症患者的工作记忆损伤

作者：尹观海¹ 方燕红¹ 张积家²

单位：1. 井冈山大学教育学院吉安 343009
2. 中国人民大学心理学系北京 100872

关键词：阿尔兹海默症工作记忆损伤

分类号：R395.2

出版年,卷(期):页码：2016,24(1):144-148

摘要：

阿尔兹海默症(AD)患者存在工作记忆损伤。受疾病损伤的程度不同,工作记忆各子成分及子功能受损的轨迹也有差异。AD患者最早表现出情景缓冲器的损伤,接着是中央执行系统受损,再是视空间画板和语音回路的损害。随着病情的恶化,工作记忆的损伤越来越严重。未来研究应注重纵向研究方法,开发专门的认知与神经任务,深入探讨各子成分及子功能随病情发展的特异性损伤趋势,揭示阿尔兹海默症与工作记忆损伤的关系,为AD患者的早期诊断及预防和治疗提供有益的指导。

Working memory(WM) deficit is a prominent feature of Alzheimer's disease(AD).Understanding the cognitive and functional impairments in AD patients is very important and may aid early diagnosis for this disease.Review of empirical findings shows that the disease has different impacts on different components, which decline in different routes.The decline of the WM is firstly associated with decrement of the episodic buffer linking capacity with the LTM.The central executive functions decrease later, followed by the impairment of visual sketchpad and phonological loop.Working memory becomes more impaired as the disease progresses.Future research into central executive functioning at early stage of AD is called for to develop tools on assessing other components of this disease.

基金项目：

获江西省社会科学"十二五"规划课题(13JY25)"不同痴呆程度的老年患者语义类别特异性损伤"、江西省教育厅科技计划项目(GJJ13551)"不同严重程度的阿尔兹海默症患者语义范畴特异性损伤研究"资助

作者简介：

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