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目的:研究早发和晚发型精神分裂症患者灰质体积的异常,寻找精神分裂症早发和晚发影响的脑区.方法:以中南大学湘雅二医院20例正常人、20例早发和20例晚发精神分裂症患者作为研究对象,性别、年龄、受教育程度等分组信息相匹配.对获取的被试脑3D结构像做逐像素分析,采用优化的基于像素的形态学分析方法,图像分割获取脑结构的灰质体积信息,然后采用8mm高斯核进行平滑处理,对平滑后的图像进行双样本t 检验,分析早发和晚发精神分裂症患者灰质体积的异常.结果:与正常人相比,精神分裂症早发患者中央前回、梭状回、舌回等相关脑区体积萎缩,颞下回、眶内额上回、额中回前部、顶下缘角回等相关脑区体积增大;而与正常人相比,晚发精神分裂患者背外侧额上回、额中回前部等相关脑区体积增加,梭状回、枕下回、颞上回、颞中回等脑区灰质体积萎缩.结论:精神分裂症患者存在多个脑区的灰质体积异常,而且不同的脑区灰质体积的异常与精神分裂症的发病时间有关.
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Objective: To study morphological abnormities in early-onset and late-onset schizophrenia, and to investi-gate the different charateristics of gray matter abnormalities between early-onset and late-onset schizophrenia patients. Methods: An experimental contrast was setup among twenty normal controls, twenty early-onset schizophrenia patients and twenty late-onset schizophrenia patients. Age, sex and years of education were well matched among three groups. Vox-el-based morphometry analysis was used to explore the morphological characteristics in three groups. Three two samplet -tests was performed to investigate the gray matter alterations in both early-onset and late-onset schizophrenia patients. Re-sults: Compared with the normal controls, it showed decreased grey matter volume in Precentral_R, Fusiform_L and Lin-gual_L, and it increased grey matter volume in Temporal_Inf_R, Frontal_Mid_Orb_L, Parietal_Inf_R, Frontal_Mid_R, Pre-central_R. compared to the normal controls, it showed decreased grey matter in Fusiform_R, Occipital_Inf_R, Tempo-ral_Pole_Sup_L, Temporal_Mid_L, Temporal_Sup_R, Occipital_Inf_R, and a increased grey matter in Frontal_Sup_Orb_L, Frontal_Mid_L. Conclusion: These findings suggest early-onset schizophrenia relate to the gray matter alterations in the fronto-pariental and fronto-temporal systems, while the late-onset schizophrenia may be related with gray matter abnormal-ities in the temporal and occipital regions.
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1 Guo XF, Li J, Wang J, et al. Hippocampal and orbital inferior frontal gray matter volume abnormalities and cognitive deficit in treatment-naive, first-episode patients with schizophrenia. Schizophrenia Research, 2014, 152(2-3): 339-343
2 魏钦令,康庄,吴小立,等. 首发和慢性精神分裂症脑白质的弥散张量成像. 中华医学杂志,2011,91(31):2186-2189
3 邝云航,李侠才,陈丽娜,等. 304例早发与晚发性精神分裂症临床对照分析. 精神医学杂志,2007,20(5):306-307
4 刘萍萍,余洪军,李娜,等. 成年早期精神分裂症首次发病患者脑灰质体积变化的初步研究. 中华精神科杂志, 2012,45(5):274-280
5 Radulescu E, Ganeshan B, Shergill SS, et al. Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia. Psychiatry Research, 2014, 223(3): 179-186
6 Job DE, Whalley HC, Johnstone EC, et al. Grey matter changes over time in high risk subjects developing schizophrenia. Neuroimage, 2005, 25(4): 1023-1030
7 刘海洪,郝以辉,欧阳萱,等. 精神分裂症患者额叶、颞叶和边缘脑区的灰质体积下降. 中国临床心理学杂志, 2009,17(5):579-580
8 Ellison-Wright I,Bullmore E. Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophrenia Research, 2010, 117(1): 1-12
9 Segall JM, Turner JA, VanErp TG, et al. Voxel-based morphometric multisite collaborative study on schizophrenia. Schizophrenia Bulletin, 2009, 35(1): 82-95
10 Tang JS, Liao YH, Zhou B, et al. Abnormal anterior cingulum integrity in first episode, early-onset schizophrenia: a diffusion tensor imaging study. Brain Research, 2010, 1343: 199-205
11 Smeets-Janssen MM, Meesters PD, Comijs HC, et al. Theory of Mind differences in older patients with early-onset and late-onset paranoid schizophrenia. International Journal of Geriatric Psychiatry, 2013, 28(11): 1141-1146
12 Vahia IV, Palmer BW, Depp C, et al. Is late-onset schizophrenia a subtype of schizophrenia? Acta Psychiatrica Scandinavica, 2010, 122(5): 414-426
13 Maglione JE, Thomas SE,Jeate DV. Late-onset schizophrenia: do recent studies support categorizing LOS as a subtype of schizophrenia? Current Opinion in Psychiatry, 2014, 27 (3): 173-178
14 Yasuda M, Kobayashi T, Kato S, et al. Clinical features of late-onset schizophrenia in Japan: comparison with earlyonset cases. Psychogeriatrics, 2013, 13(4): 244-249
15 Lui S, Deng W, Huang XQ, et al. Association of cerebral deficits with clinical symptoms in antipsychotic-naive firstepisode schizophrenia: an optimized voxel-based morphometry and resting state functional connectivity study. The American Journal of Psychiatry, 2009, 166(2): 196-205
16 Egashira K, Matsuo K, Mihara T, et al. Different and shared brain volume abnormalities in late-and early-onset schizophrenia. Neuropsychobiology, 2014. 70(3): 142-151
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