中国临床心理学杂志

clock基因rs11133391多态性与抑郁症、原发性失眠的相关研究

作者：胡义秋¹ 2 张淼¹ 朱翠英¹ 2

单位：1. 湖南农业大学教育学院长沙410128
2. 湖南省儿童青少年健康促进研究中心长沙410128

关键词：抑郁症 clock基因原发性失眠

分类号：R395.1

出版年,卷(期):页码：2015,23(5):836-838

摘要：

目的:对clock基因的rs11133391多态性位点进行分析并探讨其与抑郁症患者、原发性失眠患者的关系.方法:采用美国ABI公司的小测序SNP分型技术对155例重性抑郁症患者、105例原发性失眠患者和150名正常对照进行clock基因rs11133391位点分型,对clock基因的rs11133391的基因型和等位基因的频率进行比较.结果:抑郁症患者、原发性失眠患者与正常对照之间clock基因rs11133391多态性的等位基因与基因型没有显著差异(P >0.05);与对照组相比,原发性失眠患者rs11133391多态性的等位基因频率有显著差异(P <0.05);对rs11133391多态性三种基因型C/C、C/T、T/T抑郁症和原发性失眠的临床资料比较,显示原发性失眠患者的三种基因型之间有差异(P <0.05),其他各项没有明显差异(P >0.05).结论:clock基因rs11133391多态性可能与抑郁症的发病无关联,但与原发性失眠可能关联,且与原发性失眠患者的年龄有关.

Objective: To explore the association of clock gene with depression and Primary insomnia. Methods: The clock gene rs11133391 was genotyped by Snapshot SNP technique in 155 patients with major depression, 105 patients with Primary insomnia and 150 healthy controls. We compared the genotype and allele gene frequency in three groups. Results: There were no significant differences in genotype and allele gene in clock gene rs11133391 between depression patients and healthy controls(P >0.05); There were significant differences in allele gene in clock gene rs11133391 between Primary insomnia and healthy controls(P <0.05); There were no significant differences of clinical characteristics between three geno-types of the rs11133391 polymorphism C/C、C /T and T/T in depression patients, while in patients with Primary insomnia, significant differences in the clinical symptoms and age were found between three genotypes of the rs11133391 polymor-phism. Conclusion: Clock gene rs11133391 polymorphism may have associations with Primary insomnia, but not depres-sion.

基金项目：

2014年国家社科基金教育学项目"大学生抑郁症的易感性:社会心理因素与基因多态性的共同作用"(BBA140047);2014年湖南省教育厅科研重点项目资助(项目号:14A063)

作者简介：

参考文献：

1 Turek FW. Insomnia and depression: if it looks and walks like a duck. Sleep, 2005, 28: 1362-1363
2 李倩,傅晓燕,曲丽芳. 63例失眠患者与抑郁的相关研究. 中华中医药学刊,2013,31(1):141-143
3 Riemann D, Berger M, Voderholzer U. Sleep and depression: Results from psychobiological studies: an overview. Biological Psychology, 2001, 57: 67-103
4 胡义秋,谢光荣,詹林. Clock基因rs1801260多态性与抑郁症的关联分析. 中国临床心理学杂志,2010,18(5):591-596
5 Timo Partonen. Clock gene variants in mood and anxiety disorders. Journal of Neural Transmission, 2012, 119(10): 1133-1145
6 Louise K Sjöholm, Leena Kovanen. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. Journal of Circadian Rhythms, 2010, 8:1
7 American Psychiatric Association. The diagnostic and statistical manual of mental disorders, Fourth Edition. Washington DC: American Psychiatric Press, Incoporated, 1994
8 胡义秋,刘双金,朱翠英,刘衔华. clock基因rs3817444多态性与大学生抑郁症、原发性失眠的关联分析. 中国临床心理学杂志,2015,23(3):435-438
9 Bailer U, Wiesegger G, Leisch F, et al. No association of clock gene T3111C polymorphism and affective disorders. European Neuropsychopharmacology, 2005, 15: 51-55
10 Toshio L, Naofumi K, Makoto U, et al. Mutation screening of the human Clock gene in circadian rhythm sleep disorders. Psychiatry Research, 2002, 109(2): 121-128
11 Prinz PN. Age impairments in sleep, metabolic and immune functions. Exp Gerontol, 2004, 39: 1739-1743
12 Marina B. Neural-immune interactions in disorders of sleepwakefulness organization. Trends in Neurosciences,2007, 30 (12): 645-652

服务与反馈：

【文章下载】【加入收藏】