中国临床心理学杂志

慢性应激对小鼠行为和免疫功能的影响

作者：卢莉¹ 李敏芳²

单位：1. 山西医科大学山西太原 030001
2. 山西医科大第二医院山西太原 030001

分类号：R395.1

出版年,卷(期):页码：2009,17(3):370-371

摘要：

目的：探讨慢性应激对小鼠行为和免疫功能的影响。方法：采用束缚制动的方法建立小鼠慢性心理应激模型，通过旷场行为实验检测各组小鼠的行为变化；并处死小鼠检测其血清IFN-γ和IL-4的水平，观察应激对小鼠免疫功能的影响。结果：应激组小鼠在旷场实验中的潜伏期显著延长，探究活动减少及粪便次数增多；IFN-γ、IL-4/IFN-γ比值明显下降，而IL-4水平无显著性差异。结论：慢性心理应激可导致小鼠行为的改变并抑制小鼠的免疫功能。

Objective: To observe the effect of chronic psychological stress on change of behaviors and immunological function in mice. Methods: A stress mode was built by restrainted stress. Behavior change was evaluated, and the levels of interferon- γ (IFN- γ), interleukine-4 (IL-4) and the ratio of IL-4/IFN- γ in serum were measured. Results: Compared with the control group, restrained mice had apparently longer latency time, the exploring behavior was decreased, and times of defecation was increased. The levels of IFN- γ and the ratio IL-4/IFN- γ decreased significantly after chronic psychological stress, whereas Thymus index and IL-4 level did not change significantly. Conclusion: It is showed that chron- ic psychological stress may induce behavior changes and aggravate the suppression of immumity in mice.

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参考文献：

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