|
Objective:Recently,an intravenous abuse of buprenorphine tablets,scopolamine and promethazine solution(BSP) has been emerging among heroin-dependent individuals in some areas of Southern China.The aim of this study wasto explore the brain structural pathological changes in the patients with BSP dependence,by three dimensional MRI(3D)and compare their impairment of the brain with that of the heroin addicts.Methods:BSP-dependent patients(n=16),heroin-dependent individuals(n=20) and age/eduction-matched healthy control subjects(n=18) were assessed by 3D duringresting state.Patients with BSP and heroin dependence were examined by MRI scanning after 3 days and 2 months of abstinence,while control subjects were tested only once.Results:Compared with health controls,GMD was significantly lower in frontal,parietal,temporal and occipital lobes and striatum in the BSP addicts after 3-day withdrawal.Compared withheroin-dependent subjects,there were some brain regions showing significantly lower GMD in BSP addicts after 3-daywithdrawal.Longitudinally,BSP addicts recovered significantly slower in GMD than heroin addicts.Conclusion:GMD lesions were widespread in patients of BSP dependence.Decreased GMD in frontal,parietal cortex and striatum may contribute to neuropsychological deficits frequently observed in BSP addicts.That GMD lesions were heavier in BSP dependent subjects than those in heroin addicts suggests that cortical neuron may be vulnerable to BSP-associated brain structural changes.BSP dependent subjects’ recovering significantly slower in GMD than heroin addicts suggests that rehabilitation time should be further prolonged for BSP addicts.
|
|
[1] 周旭辉,张登科,郝伟,等.丁丙诺啡舌下片合并东莨菪碱、异丙嗪静脉注射对认知功能的影响研究.中国药物依赖性杂志,2006,15(2):35-39;
[2] Jenkinson RA,Clark NC,Fry CL,et al.Buprenorphine diversionand injection in Melbourne,Australia:an emergingissue Addiction,2005,100:197-205;
[3] Lai SH,Yao YJ,Lo DST.A survey of buprenorphine relateddeaths in Singapore.Forensic Sci International,2006,162:80-86;
[4] Bartzokis G,BecksonM,Lu PH,et al.Cortical gray mattervolumes are associated with subjective responses to cocaineinfusion.Am J Addict,2004,13:64-73;
[5] 蒋少艾,王绪轶,郝伟.海洛因成瘾者脑灰质密度的对照研究.中国药物依赖性杂志,2006,15(5):373-375;
[6] 贺忠,周旭辉,郝伟,等.海洛因依赖者停药后脑灰质密度的纵向研究.中国临床心理学杂志,2008,16(4):358-359;
[7] Lim KO,Wozniak JR,Mueller BA,et al.Brain macrostructuraland microstructural abnormalities in cocaine depen-dence.Drug Alcohol Depend,2008,92(1-3):164-172;
[8] Jang DP,Namkoong K,Kim JJ,et al.The relationship betweenbrain morphometry and neuropsychological perfor-mance in alcohol dependence.Neurosci Lett,2007,428(1):21-26;
[9] Chanraud S,Martelli C,Delain F,et al.Brain morphometryand cognitive performance in detoxified alcohol-dependentswith preserved psychosocial functioning.Neuropsychopharmacology,2007,32(2):429-438
[10] Volkow ND,Fowler JS.Addiction:A disease of compulsionand drive:Involvement of the orbitofrontal cortex.CerebralCortex,2000,10:318-325
[11] Kim SJ,Lyoo IK,Hwang J,et al.Prefrontal grey-matterchanges in short-term and long-term abstinent metham-phetamine abusers.International Journal of Neuropsychopharmacology,2005,9(2):221-228
[12] Liu X,Matochik JA,Cadet JL,London ED.Smaller volumeof prefrontal lobe in polysubstance abusers:A magnetic resonanceimaging study.Neuropsychopharmacology,1998,18(4):243-252
[13] London ED,Bonson KR,Ernst M,et al.Brain imagingstudies of cocaine abuse:Implications for medication development.Crit Rev Neurobiol,1999,13:227-242
[14] Fein G,Di Sclafani V,Meyerhoff DJ.Prefrontal cortical volumereduction associated with frontal cortex function deficitin 6-week abstinent crack-cocaine dependent men.DrugAlcohol Depend,2002,68:87-93
|